Subsequently, we found that PTPRT mutation was significantly associated with cancer metastasis in 6 common cancers, including breast cancer (BRCA), colorectal cancer (CRC), esophageal gastric cancer (EGC), non-small-cell lung cancer (NSCLC), skin cutaneous melanoma (SKCM), and skin cutaneous nonmelanoma (SKCNM). The gene discussed is PTPRT; the disease is colorectal cancer.