First, we screened the hypoxia-related genes that associated with the prognosis of pancreatic cancer using the univariate Cox regression by analyzing the 67 hypoxia-related DEGs and identified three DEGs (TES, LDHA, and ANXA2) conforming to the proportional hazards assumption were significantly related to the OS of patients with pancreatic cancer (P < 0.01). Here, ANXA2 is linked to pancreatic neoplasm.