As shown in Figure 6(d), results from GSE83452 revealed that LCP1 were positively correlated with M1 macrophages and memory B cells (P < 0.05), while negatively correlated with regulatory Tregs and CD8 T cells (P < 0.05), suggesting that LCP1 was remarkably associated with both innate immunity (macrophages, NK cells, etc.)and adaptive immune system (B cells and various types of T cells), both of which participated in the pathogenesis of NAFLD/NASH. This evidence concerns the gene CD8A and metabolic dysfunction-associated steatohepatitis.