Furthermore, NTRK1, encoding the Neurotrophic Receptor Tyrosine Kinase 1, was found to harbor a missense variant (p.T741P) of unknown significance (VUS) in the tyrosine kinase (TK) domain in tumor and matched organoids (Fig. 2b, Supplementary Fig. 3b and Supplementary Data 1). Here, NTRK1 is linked to neoplasm.