These findings have indicated that the accumulation of CerS6-derived C16:0 ceramide in WAT is involved in the obesity-related impairment of WAT function; however, an adipocyte-specific model of CerS6 deficiency has not yet been described, which is necessary to conclude adipocyte-autonomous effects of CerS6-derived C16:0 ceramides in vivo. Here, CERS6 is linked to Obesity.