In the study of gene markers of macrophages, we found that the expression of COL1A1 is weakly correlated with M1 macrophage gene markers (IRF5, COX2), but it is more moderately correlated with M2 macrophage gene markers(CD163, MS4A4A), which suggests that COL1A1 may be potential regulatory role in polarization of tumor-associated macrophages(TAM). Here, IRF5 is linked to neoplasm.