The results demonstrated that the expression of COL1A1 was significantly increased in breast invasive carcinoma (BRCA), cholangiocarcinoma (CHOL), colon adenocarcinoma (COAD), esophageal carcinoma (ESCA), head and neck squamous cell carcinoma(HNSC), kidney renal clear cell carcinoma(KIRC), liver hepatocellular carcinoma (LIHC), lung adenocarcinoma (LUAD), lung squamous cell carcinoma (LUSC), prostate adenocarcinoma (PRAD), rectum adenocarcinoma(READ), stomach adenocarcinoma (STAD) and thyroid carcinoma (THCA) in Fig 1A as compared with normal tissues. The gene discussed is COL1A1; the disease is rectum adenocarcinoma.