Based on the results of PPI network analysis and topological parameter calculation of four methods, 16 proteins were considered as hub proteins of the PPI network of MetS, including 10 up-regulated proteins (Hmgcs1, Fdps, Acat2, Mvd, Hsd17b7, Cyp2c7, Got1, Ass1, Cps1, Cth) and 6 down-regulated proteins (Cyp3a18, Cyp2b2, Cyp7a1, Ugt1a1, Ugt2b7, Aldh1a1). Here, HMGCS1 is linked to metabolic syndrome.