Finally, lipofuscin, a granule composed of lipid-containing residues of lysosomal digestion, was highly accumulated in the neurons of 6-month-old Syn1Cre; Galc flox/− mice (Fig 4F), supporting a possible connection of Krabbe disease to lipofuscinosis and age-related neurodegenerative diseases [32]. Here, GALC is linked to Krabbe disease.