In idiopathic pulmonary fibrosis and connective tissue disease related ILD, biomarkers such as surfactant protein D (SP-D), Club Cell protein 16 (CC16), and matrix metalloproteinase 7 (MMP-7) have been shown to work as diagnostic and prognostic biomarkers [20–23]. This evidence concerns the gene SFTPD and idiopathic pulmonary fibrosis.