Further, these chronic hypertensive mice showed significantly increased cardiac hypertrophy (heart weight/tibia length, Fig. S1B), fetal gene reactivation (myocardial mRNA expression levels of Myh6, Myh7 and Nppb, Fig. S1C), and fibrosis (myocardial mRNA expression of Col1a1 and Col3a1, Fig. S1D) (measured as described previously; Skaria et al., 2019) with a decreased cardiac function (ejection fraction; Fig. S1E) as described recently (Skaria et al., 2019) in addition to the previous reports describing enhanced myocardial Nppa mRNA expression post 1K1C (Wiesel et al., 1997). This evidence concerns the gene NPPA and cardiac hypertrophy.