ITGB4 and myotonic dystrophy type 1: Overall, most exons studied were significantly misspliced in adult DM1 brain samples, compared to non-DM controls: eight out of eleven exons were affected in frontal cortex (ITGB4 exon 35 and MPDZ exon 28 showed a clear trend but did not reach statistical significance) (Fig. 9d), whereas all exons studied were misspliced in the hippocampus of DM1 patients (Fig. 9e).