In this study, by integrating multi‐omics data, we profiled the genomic aberrations and the transcriptional dysregulation of 37 ATPCR encoding genes in various cancer types across the cohort of The Cancer Genome Atlas (TCGA) programme and then investigated the role of CHD7 in colorectal cancer (CRC) in depth. This evidence concerns the gene CHD7 and colorectal carcinoma.