To investigate the effect of anti‐apoptotic family members (e.g., BCL‐2 and BCL‐XL), U266 cells ectopically expressing BCL‐XL or BCL‐2 and exposed to CPT/BTZ displayed reduced PARP cleavage (Figure 2G) and significantly diminished cell death compared to controls (Figure 2H), arguing that intrinsic apoptosis contributes functionally to CPT/BTZ activity in MM cells. This evidence concerns the gene CASC3 and Miyoshi myopathy.