While NT‐proBNP is almost always elevated in HF, there are other cardiovascular disorders (e.g., acute coronary syndrome, myocarditis, arrhythmia) and noncardiovascular conditions (e.g., aging, renal disease, sepsis, anemia, liver disease) that affect BNP/NT‐proBNP levels as well. The gene discussed is NPPB; the disease is Sepsis.