Routine use of blood‐based biomarkers to assess risk of incident HF is complicated by changes in circulating levels of cTn and BNP/NT‐proBNP across the lifespan—these markers are influenced by age,54 renal function,55 body composition,56, 57 menopause,58 and pregnancy.59, 60. This evidence concerns the gene NPPB and hydrops fetalis.