Moreover, controlling for hidden confounders in modelling gene expression such as demographic traits (sex, age, race), medical comorbidities (i.e., diabetes mellitus, stroke), prescription history (e.g. cholinesterase inhibitors, which are known to modulate mitochondrial function), onset of AD disease and diagnostic modality or evaluation of RNA integrity and post-mortem interval in the included datasets was not possible, based on the lack of availability of such data in the gene expression datasets and their respective individual samples. Here, BCHE is linked to diabetes mellitus.