Presently, pharmacological (i.e. cholinesterase inhibitors, n-methyl d-aspartate receptor antagonists) and non-pharmacological (i.e. photobiomodulation, physical activity, nutritional interventions, cognitive remediation) treatments have been utilized to alleviate cognitive and musculoskeletal impairment in individuals with AD, however, these are accompanied by limited efficacy and often considerable side effects15. Here, BCHE is linked to Alzheimer disease.