Our findings revealed that the dysregulated expression of overlapping hub genes, NDUFAB1, UQCRC1, UQCRFS1, NDUFS3, and MRPL15 signified multi-algorithmic topological significance among DEGs from musculoskeletal aging and AD samples, suggesting a prominent link of the mitochondrial microenvironment between these two states. This evidence concerns the gene NDUFAB1 and Alzheimer disease.