Consistent with in vivo results, reduced lipid accumulation, as demonstrated by Oil red O staining and TG measurement, were found in UTX knockout or knockdown HK-2 cells under palmitic acid (PA) treatment-induced stress that mimics in vivo hyperlipidemia (Fig. 6a, b and Supplementary Fig. 10a–c). This evidence concerns the gene KDM6A and hyperlipidemia.