Both our results (Supplementary Fig. S13b) and a single-cell sequencing study suggested upregulated RNF114 under obesity or diabetic conditions in the kidney54, therefore, upregulated expression of UTX and RNF114 in the kidney may contribute to the enhanced degradation of PHGDH. The gene discussed is RNF114; the disease is obesity due to melanocortin 4 receptor deficiency.