Recently, upregulation of UTX has been found in the kidneys of patients with diabetic kidney disease or focal segmental glomerulosclerosis, as well as in the kidneys of mouse models of type 1 diabetes (Akita and OVE mouse) and type 2 diabetes (db/db mouse)16–18, indicating an important role of UTX in the development of diabetic kidney disease. The gene discussed is KDM6A; the disease is type 1 diabetes mellitus.