Moreover, renal Utx knockout not only ameliorated the HFD-induced kidney steatosis, but also prevented HFD-induced obesity and NAFLD due to increasing circulating serine level; renal-released serine prevented hepatocytes and renal tubular cells from lipid accumulation upon HFD stress (Figs. 1–3, 5, and 10 and Supplementary Figs. 1–3, 5). The gene discussed is KDM6A; the disease is Obesity.