MKI67 and neoplasm: The profile plot and distance-based cluster analyses also showed clusters of Ki67+ neoplastic cells distant from the drug delivery site and proximal to the macrophage–pericyte networks (Fig. 2d,e and Extended Data Fig. 4b,d), indicating that the macrophage–pericyte structures likely contribute to an increase in tumor cell proliferation in local microculture as summarized schematically in Fig. 2f.