Various studies reported that PRAME is correlated with chromosomal translocation like BCR-ABL t(9;22), PML-RARA t(15;17), and AML-ETO t(8;21) in which further investigation is needed to prove its mechanism at the molecular level as they have a significant role in the upregulation of PRAME gene. The gene discussed is RARA; the disease is acute myeloid leukemia.