The Promyelocytic leukemia zinc finger- retinoic acid receptor alpha (PLZF-RARα) and Promyelocytic leukemia-retinoic acid receptor alpha (PML-RARα) are the chimeric genes formed from the translocations of RARα in acute promyelocytic leukemia (APML) preventing cell differentiation by altering the receptors which act as vital repressors of transcription leading to cancer [10, 11]. The gene discussed is ZBTB16; the disease is acute promyelocytic leukemia.