FERMT2 and non-small cell lung carcinoma: Interestingly, our previous studies have demonstrated that Kindlin-2 is primarily localized in the mitochondria of human A549 non-small cell lung cancer cells.28 Moreover, genetic deletion of Kindlin-2 in these cells increases reactive oxygen species (ROS) production and apoptosis.28 While these findings clearly demonstrate that Kindlin-2 loss induces mitochondrial apoptosis, the underlying mechanisms require further investigations.