Hui and co-workers have reported a high Cre-recombination efficiency of AggrecanCreERT2 in condylar chondrocytes, but not in cells of articular disc, after TM injections.39 Consistently, our data show that TM-induced AggrecanCreERT2 activation significantly reduced the expression of Kindlin-2 in condylar chondrocytes, but not in cells of articular disc.41 It is well known that OA is a whole joint disease. This evidence concerns the gene FERMT2 and arthropathy.