We identified what we believe to be a novel missense SNP, rs201802880, in neutrophil cytosolic factor 1 (NCF1), also known as p47phox, that was strongly associated with SLE (OR = 3.47 and minor allele frequency [MAF] = 0.3985 in Koreans and Chinese (Pmeta = 3.1 × 10−104); OR = 2.61 and MAF = 0.0575 in White people of European descent; OR = 2.02 and MAF = 0.1570 in African Americans) and other autoimmune diseases, including primary Sjögren’s syndrome (SS) (OR = 2.45 in Chinese, OR = 2.35 in White people of European descent) and rheumatoid arthritis (RA) (OR = 1.65 in Koreans) (15). Here, NCF1 is linked to systemic lupus erythematosus.