GPER1 and schizophrenia: GPER has higher levels of expression in the brain relative to classical ERs (Hutson et al., 2019) and alteration of GPER or its signaling pathways has been found in patients with autism spectrum disorder and schizophrenia (Altun et al., 2017), suggesting that GPER may play a crucial role in the pathophysiology of these neuropsychiatric disorders.