The protective effect associated with carriage of TERT rs2242652:A remained significant after correction for sex, age, body mass index (BMI), type 2 diabetes and the top 15 PCs of genetic ancestry, but did not reach genome-wide significance (p=7.94×10−5; OR (95% CI)=0.63 (0.50 to 0.79) (online supplemental table 5) reflecting the loss of power associated with the high number of missing BMI and diabetes data points in the analysis (table 1). This evidence concerns the gene TERT and type 2 diabetes mellitus.