WNT9A and hepatocellular carcinoma: A European GWAS of HCC in ArLD, while not conforming to this exact design, was recently undertaken by Trépo et al. 14 In their discovery analysis comparing 775 HCC cases (80% with F3/F4 fibrosis) against 1332 non-HCC controls (94% with F3/F4 fibrosis), a genome-wide significant association was identified between the rs708113:T allele locus near WNT3A-WNT9A and a reduction in the risk for developing alcohol-related HCC.14