ACSL4 and cancer: We have noted that among the key enzymes, ACSL4, LPCAT3, and ALOX15, responsible for converting polyunsaturated fatty acids (PUFAs) to PUFA-OOH (the main source of lethal lipid peroxides whose production leads to ferroptosis), at least two out of the three enzymes were significantly down-regulated or unchanged in seven out of nine cancer types, except for STAD (with two enzymes up-regulated), as detailed in Table S6.