The 15q11.2 BP1-BP2 microdeletion (Burnside–Butler) syndrome is emerging as a vital pathogenic factor of congenital heart disease [1] and as the most frequent pathogenic copy number variation (CNV) in humans associated with neurodevelopmental disorders with changes in brain morphology, behavior, and cognition [4]. This evidence concerns the gene IGFBP2 and neurodevelopmental disorder.