SERPING1 and hyperinsulinemic hypoglycemia, familial, 4: Hereditary angioedema (HAE) due to C1 esterase inhibitor (C1-INH) deficiency (C1-INH-HAE) is a rare—estimated prevalence is 1:10000 to 1:50000—, autosomal dominant disorder caused by mutation in SERPING1 gene and belongs to the bradykinin mediated angioedemas [1].