Our study showed that the FKBP5 variations in combination with PCOS, with two SNP genotypes associated with PCOS generally and five for the hyperandrogenism subtype specifically, while this kind of marginal association of the FKBP5 rs1360780 and rs3800373 with PCOS patients and FKBP5 rs1360780, rs9470080, rs9296158, rs1043805, rs7757037 with hyperandrogenism subtype need to be viewed with caution before further validation and subsequent experimentation are conducted. The gene discussed is FKBP5; the disease is polycystic ovary syndrome.