In our study, inversely, the frequency of the TT genotype of FKBP5 SNP rs9470080 and the TT genotype of rs1360780 was significantly higher in PCOS NHA group than PCOS HA group, and the TT of rs1043805, the GG of rs7757037 showed the same tendency. Here, FKBP5 is linked to polycystic ovary syndrome.