As core fucosylation on the cell surface is critical for CD4+ T cell activation (Fujii et al., 2016; Liang et al., 2018) and activated cells are more permissive to HIV infection (Stevenson et al., 1990), HIV may upregulate fucosylation to maintain an elevated state of activation facilitating the completion of its replication. Here, CD4 is linked to HIV infectious disease.