PTEN and overgrowth syndrome: Seven patients (23%) had documentation of clinical diagnoses of overgrowth syndromes including Congenital Lipomatous Overgrowth with Vascular, Epidermal, and Skeletal anomalies (termed CLOVES), Klippel–Trenaunay syndrome, and phosphatase and tensin homolog (PTEN)-like hamartoma syndrome at the time of testing.