TP53 and colorectal carcinoma: To see whether this induction of ETC complexes also occurs in vivo, we transplanted short-term cultured human CRC cells (HROC24 (p53 wild-type) and HROC87 (p53 mutated) [38]) in mice, treated them with irinotecan, excised the tumors, and probed for ETC proteins by immunoblot.