We found that self-renewal of microglia did not improve amyloid pathology, evidenced by the unaltered area fraction occupied by amyloid plaques, as well as the average size and number of plaques in either male 3xTg (Fig. 1B–E, G–I) or APP/PS1 mice of both sexes (Fig. 2B–E and Additional file 2: Fig. S2A–D). Here, PSEN1 is linked to amyloidosis.