Thus, our data add to previous findings and suggest no clear benefit of repopulation to amyloid pathology or cognitive outcomes (Figs. 1, 2 and Additional file 2: Fig. S2, Additional file 3: Fig. S3, and Additional file 4: Fig. S4) in 3xTg or APP/PS1 models of AD at stages of advanced pathology. The gene discussed is APP; the disease is Alzheimer disease.