After four weeks, DIZE treatment decreased the infarction area and improved the ventricular contractility by increasing the activity of plasma and myocardial ACE2, raising myocardial ACE2 and MasR mRNA levels, and depressing myocardial expression of ACE and AT1R mRNA compared to the myocardial infarction group. Here, MAS1L is linked to myocardial infarction.