Since impaired mitophagy contributes to the early AD related pathology [49] which can be ameliorated by mitophagy inducers [50] and decorin could activate mitophagy in breast carcinoma cells [41, 51], it will be interesting to analyze mitophagy alterations by decorin in the neurons which may give us a clue if decorin can be a potential therapeutic target for the early AD. Here, DCN is linked to Alzheimer disease.