To assess this finding in a different way, we performed immunohistochemical staining for CHCHD10 together with phospho-TDP-43 in the frontal cortex of 4 frontotemporal lobar degeneration-TDP (FTLD-TDP) cases, 5 nondemented control cases, and 3 Alzheimer’s disease (AD) cases using TrueBlack® to eliminate background autofluorescence (Case information: Additional file 1: Fig. S1a). Here, CHCHD10 is linked to early-onset autosomal dominant Alzheimer disease.