Our findings from FTLD-TDP and AD cases showing robust colocalization phospho-TDP-43 pathology with CHCHD10 inclusions (~ 75–84%) and tight correlation between insoluble CHCHD10 with insoluble TDP-43 indeed indicates a pathological link between them in human neurodegenerative diseases. The gene discussed is CHCHD10; the disease is neurodegenerative disease.