Conversely, MOC for the proportion of CHCHD10 colocalizing with phospho-TDP-43 was 0.18 in FTLD-TDP and 0.08 in AD (Fig. 1e), indicating that while only ~ 18% of CHCHD10 colocalizes with phospho-TDP-43 in FTLD-TDP, a significantly larger proportion of CHCHD10 colocalizes with phospho-TDP-43 in FTLD-TDP versus in AD. Here, CHCHD10 is linked to Alzheimer disease.