Beyond TDP-43-related spectrum disorders, our mechanistic model may also help to shed light on the diversity of disease phenotypes associated with CHCHD10 mutations, such as mitochondrial myopathy [55], spinal muscular atrophy (SMA) [56], and Charcot-Marie-Tooth disease type 2 (CMT2) [57]. Here, CHCHD10 is linked to spinal muscular atrophy.