Overall, Manders overlap coefficient (MOC) for phospho-TDP-43 colocalization with CHCHD10 reached 0.75 in FTLD-TDP and 0.84 in AD with no significant difference between them (Fig. 1d), indicating that most phospho-TDP-43 inclusions contain CHCHD10 in both FTLD-TDP and AD. Here, TARDBP is linked to Alzheimer disease.