As our earlier study found that detergent soluble CHCHD10 levels significantly decline in brains of FTLD-TDP patients and TDP-43 transgenic mice, we initially looked for changes in CHCHD10 staining together with phospho-TDP-43 staining in brains of FTLD-TDP, AD, and nondemented controls. This evidence concerns the gene CHCHD10 and Alzheimer disease.