Interestingly, ectopic TDP-43 expression recapitulates the effects of FTD/ALS-linked CHCHD10 mutations in disrupting mitochondrial fusion, cristae integrity, and respiration, whereas CHCHD10WT rescues these mitochondrial abnormalities induced by TDP-43 [26]. The gene discussed is CHCHD10; the disease is frontotemporal dementia.