In 2015, Zmuda et al. introducednovel radio-iodinated tracers withspecificity to PARP-1 for GBM imaging.101 Olaparib (163), a clinical PARP-1 inhibitor, was usedas a lead, and a series of olaparib analogs were synthesized bearingvarious substitutions. This evidence concerns the gene PARP1 and glioblastoma.