PRRT2 and glioblastoma: • PKC is a serine/threoninekinase that is highly expressedin GBM, resulting in the proliferation, survival, invasion, and migrationof GBM cells.233 The isoforms of PKC areinvolved in the chemoresistance through various pathways, the contributionsof which depend on phosphorylation of tyrosine residues.234 This understanding of PKC makes it an promisingtarget against GBM.235