In 2017, Daniele et al.revealed a dual inhibitor of PDK1 and aurorakinase (148) that inhibited the growth of U343MG andANGM-CSS (an immortal cell line derived from a human GBM), with IC50 = 49.7 and 44.0 nM, respectively (Figure 37B).88 Additionally, 148 displayed a significant effect on cancer cell proliferation,triggered cellular apoptosis, and reduced tumor invasiveness. Here, PDK1 is linked to glioblastoma.