Lee et al. identified a cocktail of forskolin, ISX9, CHIR99021I-BET 151, and DAPT that successfully reprogrammed malignant cellsinto neurons.328 The involvement of smallmolecules in GBM cell reprogramming promotes the applicability ofsmall molecules and opens the door for medicinal chemists to designsynthetically relevant reprogrammable scaffolds for GBM. Here, DNER is linked to glioblastoma.