Theinduction of cell death, cell cycle arrest, and a cellular differentiationphenotype was observed with corin treatment along with transcriptionalchanges correlating with increased survival time in DIPG patients.The outcome of this study clearly shows that dual HDAC-LSD1 inhibitionis a logical strategy to treat DIPG.87 The gene discussed is KDM1A; the disease is diffuse intrinsic pontine glioma.