HDAC6 and central nervous system cancer: In additionto scaffold assembly studies, some efforts have alsobeen directed toward the determination of HDAC6 expression in GBM.Auzmendi-Iriarte et al. conducted HDAC6 expression analysis in GBMusing the Rembrandt cohort (28 control and 219 GBM samples), TCGAcohort (4 control and 156 GBM samples), Gravendol cohort (8 controlsamples and 24 grade II, 85 grade III, and 159 grade IV glioma samples),vital cohort, and Donson cohort.61 Theresults revealed that GBM samples contained high expression of HDAC6,and HDAC6 overexpression correlated with advanced glioma grade andpoor patient survival.