Notably, these research groupshave conducted a series of studies on kinase inhibitors as anti-GBMagents, and their efforts have led to the identification of potentadducts worthy of detailed investigation.45−53 Another target that has been reasonably utilized for the constructionof anti-GBM agents in the recent past is histone deacetylase (HDAC).54−61 The drug design strategies for HDAC inhibitors discussed in thisPerspective clearly depict the flexibility of the three-componentHDAC inhibitory model. This evidence concerns the gene HDAC9 and glioblastoma.