PTEN and neoplasm: FAK regulates the survival, proliferation, migration,invasion, and microenvironment of tumor cells like angiogenesis.493−498 Tamura et al. revealed the involvement of phosphatase and tensinhomolog (PTEN) in the dephosphorylation of active FAK at Y397 in GBMcell lines.498 In the active and phosphorylatedstate, it increases the expression of CCND1/cyclin-D1 and decreasesthe levels of p21/CDKN1A cyclin-dependent kinase (CDK) inhibitor,causing enhanced proliferation of cells through accelerated transitionfrom the G1-S phase.499 Mamillapalli etal.