The additional involvement in the deletion peaks of tumorsuppressor genes (CDKN2A, TUSC1, PTEN, CDKN2B, BNIP3, and FAS) suggeststhe importance of PDI in the malignant processes of GBM, includingendoplasmic reticulum (ER)-associated degradation, unfolded proteinresponse, cell adhesion, endoplasmic reticulum stress (ERS), WNT signalingpathways, DNA sensing (cytosolic), and apoptosis. The gene discussed is P4HB; the disease is glioblastoma.