PARP1 and glioblastoma: Notably,at the preliminary and preclinical levels, medicinal chemists haveexplored synthetic adducts as well as natural product libraries tofurnish new chemical architectures for the treatment of GBM.93−100 Imaging tools and chemical probes for GBM (radio-iodinated tracerswith specificity to PARP-1,101 microtubules,10218F-labeled radiotracers,103 carborane-containing boron dipyrromethenes,104,105 and cyanine–gemcitabine106) havealso been generated.