• Impaired functioning of p53 tumorsuppressor througheither genetic mutation or sequestration by other protein leads todevelopment of cancer and chemoresistance. p53 availability is generallyreduced in GBM due to binding to MDM2 oncoprotein that gets accumulatedin the tumor cells at high concentrations. These revelations certainlypresent the inhibition of MDM2 as a logical strategy to design therapeuticsfor GBM.297,304. The gene discussed is MDM2; the disease is cancer.