BRD2 and glioblastoma: • It is well known that BET bromodomain proteins recognizelysine-acetylated histones and regulate gene expression. Some studieshave reported elevated levels of bromodomain proteins BRD2 and BRD4in GBM. In light of the aforementioned, BET protein inhibition isbeing considered as a prudent strategy to emerge as a potential therapeuticapproach for GBM patients that experience TMZ-resistant tumors.285 Both small-molecule inhibitors and degradersof the BET proteins have garnered the attention of researchers inthe recent past.