SB747651A(147) is a multi-targeted small molecule that inhibitsmultiple pathways, including the MAPK, PI3K-Akt-mTOR, and JNK pathways.The team investigated this molecule using three well-characterizedpatient-derived GBM spheroid cultures (T111, T86, and T78). The gene discussed is PIK3CA; the disease is glioblastoma.