• Another stimulatory checkpoint moleculeis the glucocorticoid-inducedTNFR-related gene, which acts by increasing Treg cell proliferation.OX4OL is another stimulatory checkpoint molecule which is associatedwith prolonged survival in murine models for GBM. Hence, exploringmore about stimulatory checkpoint molecules as potential biomarkerscan be another helpful strategy for GBM treatment.213,226. This evidence concerns the gene TNFSF4 and glioblastoma.