• Raf proto-oncogene(RAF),242 mitogen-activated protein kinase(MAPK),243 p38 MAP kinase/mitogen-activatedprotein kinase 14 (p38MAPK),244 mechanistictarget for rapamycin kinase 1 (mTORC),245 cyclin-dependent kinase 4/6 (CDK 4/6),246 Wee1 G2 checkpoint kinase (Wee1),247 proteinkinase C beta (PRKCB),235 and DNA-dependentprotein kinase (DNA-PK)248 represent theprominent targets for GBM belongingto this category. This evidence concerns the gene PRKDC and glioblastoma.