Encouraged by the involvement of PDI in GBM, Yang et al. unveileda novel series of allosteric PD1 inhibitors to treat GBM.71 The research group conducted a SAR study onthe previously identified PDI inhibitor BAP-2 (90), obtainedfrom a high-throughput screening (IC50 = 930 nM). The gene discussed is PDCD1; the disease is glioblastoma.