The overexpression of PDI6 is involved inthe progression, invasion,and migration of GBM cells.525 The relationshipbetween clinical–pathological outcomes of GBM and mRNA expressionof PDIs studied in the CGGA and TCGA database analysis indicated thatthe somatic alterations in the GBM (high PDI signature and risk score)are involved in the aberrations of driver oncogenes PIK3CA, MUC16,and TTN and amplification peaks of oncogenes (PDGFRA, PIK3C2B, CDK4,and EGFR). The gene discussed is CDK4; the disease is glioblastoma.