HIF1A and glioblastoma: • LSD1 represents another epigenetictarget that hasbeen found to exert favorable trends via a chemical strategy affordingits inhibition. As such, LSD1 is a histone modifier that activelyparticipates in the process of gene transcription along with the regulationof methylation dynamics of non-histone proteins. A recent study reportedinduction of senescence in GBM via LSD1 inhibition through a HIF-1α-dependentpathway.286