• Recently, delivery of chitosannanoparticles loadedwith siRNAs by targeting galectin-1 was reported. The results of theexploration revealed significant decreases in the expression of galectin-1in the tumor microenvironment. Overall, these results were quite optimisticand strengthened the candidature of intra-nasal gene delivery usingnanoparticles as a prudent methodology for the treatment of GBM.570. This evidence concerns the gene LGALS1 and glioblastoma.