In 2013, Campos et al. designed curcumin-basedligands and synthesized them using metal-catalyzed multi-componentreactions.96 The synthesized adducts wereevaluated for their cell growth inhibitory effects against GBM celllines (U-87-MG, U-87-MG sh-gfp, and U-87-MG sh-p53) and neuroblastomacell lines (SK-N-SH and SK-N-F1). The gene discussed is TP53; the disease is glioblastoma.