In 2021, Li et al. investigated four nimesulide analogs to treatGBM.109 In their previous studies, thesefour compounds were identified as dual HSP27 and tubulin inhibitors.In the present study, the authors planned to evaluate the abilityof the compounds to modulate androgen receptor function in GBM cells.Compounds 190–193 were tested againstfour GBM cell lines, and they showed relatively better inhibitoryeffects toward T98G cells (Figure 49). The gene discussed is AR; the disease is glioblastoma.