EZH2 and central nervous system cancer: • EZH2, a crux subunit of the PRC2, is a HMT enzymeresponsible for methylating lysine 27 (mono-, di-, and trimethylation)in histone H3 (H3K27) and is involved in regulation of cell stemnessand epithelial-to-mesenchymal transition (EMT) in gliomas.