CDKN1B and glioblastoma: Accordingto a study conducted by Alza et al., PF-573228 (an FAK inhibitor)arrests cell proliferation, increases the size of cells, and diminishesneurosphere growth in GBM due to an increase in the levels of β-galactosidaseand p27/CDKN1B activity.501 The inhibitionof FAK also reduces p62/SQSTM-1 expression (autophagy cargo receptor),stimulating p27 transcriptional upregulation (senescent-like phenotype)and leading to proliferation arrest and cell death.