Microglia dysfunction is also prominent in other neuropathologies, including schizophrenia (increased microglial activity and density, elevated expression of proinflammatory cytokines) [38, 39], Parkinson’s disease (increased activation in the substantia nigra by alpha-synuclein, proinflammatory profile) [40, 41], Alzheimer’s disease (increased activation, synaptic remodeling) [42–44], and multiple sclerosis (increased activation profile and oxidative stress) [45, 46]. This evidence concerns the gene SNCA and Parkinson disease.