A dysfunctional immune response by monocytes and other innate immune cells resulting in a delayed interferon response, an increase in proinflammatory cytokines and chemokines such as IL-1-β, TNF-α, CXCL-10, IL-10, IL-18, IL-8 with an increase in many inflammatory lipid mediators is seen in patients who progress to develop severe forms of dengue (DHF) [57, 61, 84]. This evidence concerns the gene CXCL10 and dengue disease.