Many inflammatory lipid mediators such as platelet activating factor (PAF), vascular endothelial growth factor (VEGF), angiopoietin-2 (Ang-2) has shown to cause endothelial dysfunction and phospholipase A2 enzymes that generate PAF were shown to be elevated during early illness in dengue [57, 58, 85]. This evidence concerns the gene ANGPT2 and dengue disease.