To further verify which circRNAs participated in the occurrence of pulpitis, the circRNA-miRNA-mRNA linkage was plotted using Cytoscape, in which the differential expression circRNAs were chosen by adhering to these guidelines: (1) the number of envisaged binding locations of circRNAs to miRNAs, and miRNAs to mRNAs was more than three; (2) The gene was envisaged to participate in pulpitis linked signaling pathway, including TNF, NF-κB, NLRP3 inflammasome, MAPK, and Wnt signaling pathways [25–28]. The gene discussed is NLRP3; the disease is pulpitis.