In anin vivostudy, hyperglycemia, one of the characteristics of DM, was associated with decreased expression of Runt-related transcription factor 2 (RUNX2), where the transcription factor of this gene is the “master regulator” of osteoblast development.20Osterix is another transcription factor that plays important role in osteoblast differentiation and matrix mineralization. This evidence concerns the gene RUNX2 and Hyperglycemia.