RUNX2 and diabetes mellitus: In anin vivostudy, hyperglycemia, one of the characteristics of DM, was associated with decreased expression of Runt-related transcription factor 2 (RUNX2), where the transcription factor of this gene is the “master regulator” of osteoblast development.20Osterix is another transcription factor that plays important role in osteoblast differentiation and matrix mineralization.