TBI‐induced ARDS was also associated with alteration in TIMP3 (Hendrickson et al., 2018), reduction of circulating microparticles (Midura et al., 2015), changes in APC (activated protein C) (Finigan, 2009) and HMGB1 (Braun et al., 2017). This evidence concerns the gene APC and acute respiratory distress syndrome.