Of note, 8 of these 23 genes (ERBB2, ESR1, AKT1, PIK3CA, RB1, TP53, BRCA2, BRCA1) specifically overlapped with the BC annotated gene set (Figure S6 and Table S6, Supporting Information) in both WikiPathway cancer and KEGG. The gene discussed is PIK3CA; the disease is breast cancer.