In this large population‐based series of CRC patients, we therefore aimed to (1) study the association between mutational subgroups based on the presence of somatic mutations in RAS (KRAS, NRAS, HRAS), BRAF, PIK3CA, and MET, as well as MMR status, and survival, and (2) to study the relationship between previously identified Warburg‐subtypes and survival within these mutational subgroups to examine whether Warburg‐subtypes provide additional prognostic information. The gene discussed is PIK3CA; the disease is colorectal carcinoma.