We hypothesized that (1) mutational subgroups based on somatic mutations in RAS, BRAF, PIK3CA, and MET, which are known to promote the Warburg‐effect,12, 13, 14, 15 as well as patients' mismatch repair (MMR) status, may hold prognostic value in CRC, and (2) Warburg‐subtypes may provide additional prognostic information within these mutational subgroups, independent of known prognostic factors like TNM stage. Here, PIK3CA is linked to colorectal carcinoma.