In both vaccines and natural infections, inflammasome‐derived IL‐1β and associated receptors play a key role in transmitting stimulatory signals between innate and adaptive immune cells (Ichinohe et al, 2009; Reed et al, 2013; Munoz‐Wolf & Lavelle, 2018; Van Den Eeckhout et al, 2020; Pulendran et al, 2021). The gene discussed is IL1B; the disease is infection.