- Cerebral cortical encephalitis is a less common phenotype, also known as FLAMES (unilateral cortical FLAIR-hyperintense Lesions in Anti-MOG-associated Encephalitis with Seizures), characterized by encephalopathy, seizures, headache, marked CSF pleocytosis, and cortical hyperintensity on FLAIR images (82, 83). Here, MOG is linked to Encephalopathy.