AQP4 and myelitis: Table 1 summarizes and compares the main clinical, laboratory, and MRI features generally observed in patients with MOGAD, AQP4-IgG+NMOSD, and MS; while examples of typical MRI abnormalities seen in MOGAD patients with ON, brain, and myelitis attacks compared to AQP4-IgG+NMOSD and MS are shown in Figures 2–4, respectively (61, 62).