AQP4 and Autoimmunity: This is also in line with rare cases of MOG-IgG coexisting with other autoantibodies (e.g., AQP4-IgG, NMDAR-IgG) where the clinical-MRI phenotype is typically predicted by the accompanying antibody, although overlapping features may occur (see also “Coexisting autoimmunity” above) (45, 147).