Children or younger CACH/VWM patients with “ovarian dysgenesis” or “bilateral streak ovaries” (10, 21, 32–35), early LVWM with ovarian failure without genetic testing information 10, EIF2B5 gene variants related adult late-onset LVWM sporadic or family studies without ovarian failure evidence (2, 11, 36, 37), were not included in the present literature review. Here, EIF2B5 is linked to ovarian dysfunction.