LRP2 and plasma cell myeloma: In addition to these chemical stressors, silencing of megalin and cubulin has been shown to inhibit myeloma light chain endocytosis and reduce the toxicity of myeloma light chains (Li et al., 2008), which are exessively produced in multiple myeloma and may cause proximal tubule alterations through overload of the endocytic process (Batuman, 2007).