Additionally, Wnt-1, β-catenin, cyclin-D1, MMP2, and MMP9 as well as Ki-67 levels were higher in tumor cells of the model + sh-SOST group than that of the model + sh-NC group, demonstrating that SOST suppression was capable of activating Wnt/β-catenin signaling in ocular orthotopic tumor models. This evidence concerns the gene MMP2 and neoplasm.