To assess vascular density and stemness in accordance with tumor oxygenation, the expression levels of FOXM1, nestin, CD34, CA9, and HIF-1α were analyzed with immunohistochemistry using paired samples from the same patients treated with neoBev followed by surgery, RT, TMZ, and TMZ/Bev combined therapy, and then salvage surgery or autopsy at the time of recurrence after Bev (Figure 3). This evidence concerns the gene HIF1A and neoplasm.