VSIR and lymphoma: Among the recent discovered genes, V-domain Ig suppressor of T cell activation (VISTA) exerts its activity by decreasing the production of cytokines by T cells and by reducing their proliferation (130) it has been shown to be highly expressed on the epithelioid subtype and an ongoing phase I clinical trial (NCT02812875) aimed at studying the efficacy of a small molecule inhibitor against VISTA in patients with advanced solid tumors or lymphomas (131).