HCC, breast cancer, ovarian cancer, and colorectal cancer (CRC) display increased levels of transferrin receptor and aberrant expression of other iron transport–related proteins such as ferroportin (iron export transmembrane protein) and the divalent metal transporter (DMT1), required for iron uptake into enterocytes and transport across the endosomal membrane once iron is taken up by the cell (173) Figure 1B (174–176). The gene discussed is TFRC; the disease is ovarian cancer.